Hyaluronic acid is a major component of synovial fluid around the joints, helping to cushion the joints, absorb shocks and reduce friction between cartilage and bones. High molecular weight hyaluronic acid has been shown to boost tendon repair and reduce inflammation in vitro. In another study, supplementing with hyaluronic acid for 3 months slowed down the progression of osteoarthritis in cartilage by modulating genes in the extracellular matrix and also increased the levels of hyaluronic acid in synovial fluid around the joints. High molecular weight hyaluronic acid may reduce inflammation by down-regulating proinflammatory cytokines through interactions with TLR-4.

Hyaluronic acid has been used in eye drops and in contact lenses for years, to try and alleviate dry eye disease. Dry eye disease increases with age, rising steeply from about 50 years old. A pilot study found that combined oral and topical hyaluronic acid treatment was significantly more effective than just topical hyaluronic acid alone for dry eye disease. The study used 240mg of hyaluronic acid with molecular weight of 390 kDA and there were significant improvements in the ocular surface disease index in just one month compared to the placebo group.

Hyaluronic acid is present in high concentrations in the lung connective tissue and is crucial for lung health for several reasons. It’s moisture absorption properties help with lung tissue moisture control and healing. It also helps increase the volume of airway surface liquid, supporting mucus transport and hydration. Hyaluronic acid can retain a significant quantity of water in the extracellular matrix, producing viscous gels that may play important roles in both the homeostasis of the tissues and their biomechanical integrity.
It's anti-inflammatory properties may help with respiratory conditions such as asthma and chronic obstructive progressive lung disease.

The body’s natural production of hyaluronic acid increases in response to injury and wound healing. Hyaluronic acid actually regulates several aspects of tissue repair, including the immune response and amount of inflammation. It also provides the framework for the formation of new blood vessels.
Most of the hyaluronic acid in the skin is in the dermis, where it regulates the water balance, osmotic pressure, electrolyte flow and also acts as a sort of sieve, allowing the transport of certain molecules and not others. Greater levels of hyaluronic acid increases scar-free tissue repair.

Taking hyaluronic acid supplements helps reduce the appearance of wrinkles by improving both skin hydration and elasticity. Its ability to attract and retain water increases skin hydration from the inside out. Some double-blind, placebo-controlled studies have shown that oral hyaluronic acid supplementation can lead to noticeable improvements in skin texture, wrinkle depths and overall hydration levels.

Taking hyaluronic acid supplements helps reduce the appearance of wrinkles by improving both skin hydration and elasticity. Its ability to attract and retain water increases skin hydration from the inside out. Some double-blind, placebo-controlled studies have shown that oral hyaluronic acid supplementation can lead to noticeable improvements in skin texture, wrinkle depths and overall hydration levels.